Wednesday, July 27, 2011

The drug industry, in a nutshell

Lu AA12004 is one of the few new (3 in the last decade) anti-depressant drugs about to go to market. They are tested by "Clinical trial".

"If you ask me, this study should have compared the new drug to an SSRI, because they're used much more widely than venlafaxine. ... although there are no fewer than 26 registered clinical trials of Lu AA21004 either ongoing or completed, only one is comparing it to an SSRI. "

Pharmacologically, Lu AA21004 is kind of a new twist on an old classic . Its main mechanism of action is inhibiting the reuptake of serotonin, just like Prozac and other SSRIs. However, unlike them, it also blocks serotonin 5HT3 and 5HT7 receptors, activates 5HT1A receptors and partially agonizes 5HT1B.

Basically, the main problem with Lu AA21004 was that it made people sick. Literally - 9% of people on the highest dose suffered vomiting, and 38% got nausea. However, the 5 mg dose was no worse than venlafaxine for nausea, and was relatively vomit-free. Unlike venlafaxine, it didn't cause dry mouth, constipation, or sexual problems.

Yeah. This is what a body needs.

Friday, July 1, 2011


- Posted using BlogPress from my iPhone